References

Petrie A, Watson PFOxford: Wiley Blackwell; 2006
Bland JM, Altman DG Measuring agreement in method comparison studies. Stat Methods Med Research. 1999; 8:(2)135-160
Harris EF, Smith RN Accounting for measurement error: a critical but often overlooked process. Arch Oral Biol. 2009; 54:s107-s117

Useful concepts for critical appraisal: 3. association, outcomes and errors

From Volume 5, Issue 4, October 2012 | Pages 113-117

Authors

Archna Suchak

BSc(Hons), BDS(Hons), MFDS, MSc, MOrth RCS, FOrth RCS

Locum Consultant Orthodontist, Great Ormond Street Hospital, London

Articles by Archna Suchak

Ama Johal

BDS, PhD, FDS(Orth) RCS

Senior Lecturer, Department of Oral Growth and Development, Bart's and The London School of Medicine and Dentistry, Institute of Dentistry, Queen Mary's College, London, UK

Articles by Ama Johal

Angie Wade

BSc, MSc, PhD, CStat ILTM

Senior Lecturer in Medical Statistics, Institute of Child Health, University College London, London, UK

Articles by Angie Wade

Abstract

There is an increasing volume of research undertaken within orthodontics and with this comes a need to evaluate what is available. This short series aims to help the orthodontist revise basic concepts of critical appraisal and pertinent statistics.

Clinical Relevance: Critical appraisal skills are valuable tools that can aid clinical decision-making. In this final article, we review ways in which associations and outcomes are commonly presented and discuss various types of error studies.

Article

Correlation is concerned with the strength of linear association between two variables measured on the same individual. By convention, the variables are plotted on a scatterplot so that the independent (explanatory) variable is on the x-axis and the dependent (response) variable is on the y-axis (Figure 1).

A correlation coefficient can be calculated to describe the magnitude and direction of any linear association, but it cannot suggest whether the relationship is causal. Hypothesis tests for correlation can be undertaken and a p-value may be displayed in the results: the null hypothesis presumes there is no linear association whatsoever. Both parametric and non-parametric versions of correlation coefficient exist:

Regression models can be used to describe the relationship between two or more variables: x (the independent variable/s) and y (the dependent variable) via an equation (Box 1).

The independent explanatory variables may be numeric, categoric or a mixture. The appropriate regression model to use depends on the type of the outcome variable:

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