Abstract
This case report describes a 13-year-old patient suffering from osteogenesis imperfecta (OI) and hypodontia. Different issues related to clinical presentation and orthodontic treatment of patients with OI are discussed in this report.
References
Majorana A, Bardellini E, Brunelli PC, Lacaita M, Cazzolla AP, Favia G. Dentinogenesis imperfecta in children with osteogenesis imperfecta: a clinical and ultrastructural study. Int J Paediatr Dent. 2010; 20:112-118
Huber MA. Osteogenesis imperfecta. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 103:314-320
Malmgren B, Norgren S. Dental aberrations in children and adolescents with osteogenesis imperfecta. Acta Odontol Scand. 2002; 60:65-71
Teixeira CS, Santos Felippe MC, Felippe WT, Silva-Sousa YT, Sousa-Neto MD. The role of dentists in diagnosing osteogenesis imperfecta in patients with dentinogenesis imperfecta. J Am Dent Assoc. 2008; 139:906-914
Saeves R, Lande Wekre L, Ambjornsen E, Axelsson S, Nordgarden H, Storhaug K. Oral findings in adults with osteogenesis imperfecta. Spec Care Dentist. 2009; 29:102-108
Seikaly MG, Kopanati S, Salhab N, Waber P, Patterson D, Browne R Impact of alendronate on quality of life in children with osteogenesis imperfecta. J Pediatr Orthop. 2005; 25:786-791
O'Connell AC, Marini JC. Evaluation of oral problems in an osteogenesis imperfecta population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999; 87:189-196
Kindelan J, Tobin M, Roberts-Harry D, Loukota RA. Orthodontic and orthognathic management of a patient with osteogenesis imperfecta and dentinogenesis imperfecta: a case report. J Orthod. 2003; 30:291-296
Abdelmalek NF, Gerber TL, Menter A. Cardiocutaneous syndromes and associations. J Am Acad Dermatol. 2002; 46:161-183
Morton ME. Excessive bleeding after surgery in osteogenesis imperfecta. Br J Oral Maxillofac Surg. 1987; 25:507-511
Prince SE, Simpson MT. Osteogenesis imperfecta. Br J Oral Maxillofac Surg. 2000; 38:399-400
Shields ED, Bixler D, El-Kafrawy AM. A proposed classification for heritable human dentine defects with a description of a new entity. Archs Oral Biol. 1973; 18:543-553
Ogunsalu C, Hanchard B. Familial tarda type osteogenesis imperfecta with dentinogenesis imperfecta type I. Case report. Aust Dent J. 1997; 42:175-177
Tanaka T, Murakami T. Radiological features of hereditary opalescent dentin. Dentomaxillofac Radiol. 1998; 27:251-253
Cauwels RG, De Coster PJ, Mortier GR, Marks LA, Martens LC. Dentinogenesis imperfecta associated with short stature, hearing loss and mental retardation: a new syndrome with autosomal recessive inheritance?. J Oral Pathol Med. 2005; 34:444-446
Hart PS, Hart TC. Disorders of human dentin. Cells Tissues Organs. 2007; 186:70-77
Waltimo J, Ojanotko-Harri A, Lukinmaa PL. Mild forms of dentinogenesis imperfecta in association with osteogenesis imperfecta as characterized by light and transmission electron microscopy. J Oral Pathol Med. 1996; 25:256-264
Sillence DO, Senn A, Danks DM. Genetic heterogeneity in osteogenesis imperfecta. J Med Genet. 1979; 16:101-116
Glorieux FH, Rauch F, Plotkin H, Ward L, Travers R, Roughley P Type V osteogenesis imperfecta: a new form of brittle bone disease. J Bone Miner Res. 2000; 15:1650-1658
Glorieux FH, Ward LM, Rauch F, Lalic L, Roughley PJ, Travers R. Osteogenesis imperfecta type VI: a form of brittle bone disease with a mineralization defect. J Bone Miner Res. 2002; 17:30-38
Ward LM, Rauch F, Travers R, Chabot G, Azouz EM, Lalic L Osteogenesis imperfecta type VII: an autosomal recessive form of brittle bone disease. Bone. 2002; 31:12-18
Rauch F, Glorieux FH. Osteogenesis imperfecta. Lancet. 2004; 363:1377-1385
Schwartz S, Tsipouras P. Oral findings in osteogenesis imperfecta. Oral Surg. 1984; 57:161-167
A review of osteogenesis imperfecta in relation to orthodontic treatment
From Volume 6, Issue 1, January 2013 | Pages 21-24
Article
Osteogenesis imperfecta (OI) known as ‘brittle bone disease’ is defined as a group of heritable connective tissue disorders, caused by a defect in the synthesis of type I collagen. The most common causes of this condition are mutations of the genes COL1A1 and COL1A2 that encode chains of type I collagen.1 Because of the variety in clinical presentation and the emergence of new genetic mutations, the exact incidence of OI is unknown. However, an incidence rate of 1:5000 to 1:20,000 live births was reported by different authors.2,3
Patients with OI may show a plethora of signs and symptoms related to the defective collagen present in different structures of the body, including bone, sclera, skin, ligaments, blood platelets, auditory ossicles, inner ear and teeth. Thus, the signs and symptoms include:
OI is classified on the basis of clinical, genetic and radiographic features.1 Sillence et al18 divided OI into four types. Since then further types have been added:
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