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References

Vasconcelos R, Vasconcelos M, Queiroz L. Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment. Journal Brasileiro de Patologiae Medicina Laboratorial. 2013; 49:446-452
Grimes D, Aulakh GS, Hayter J. Spontaneous resolution of a central giant cell lesion: case report. Br J Oral Maxillofac Surg. 2017; 55:220-221 https://doi.org/10.1016/j.bjoms.2016.07.009
Wang Y, Le A, El Demellawy D An aggressive central giant cell granuloma in a pediatric patient: case report and review of literature. J Otolaryngol Head Neck Surg. 2019; 48 https://doi.org/10.1186/s40463-019-0356-5
Kalele K, Kanakdande V, Patil K. Peripheral giant cell granuloma: a comprehensive review of an ambiguous lesion. J Int Clin Dent Res Org. 2014; 6
Scully C. Lumps and swellings in the jaws.Edinburgh: Churchill Livingstone/Elsevier; 2013
Weidner N. Modern Surgical Pathology.Philadelphia, PA, USA: Saunders/Elsevier; 2009
Neville B, Damm DD, Allen C, Chi A. Bone pathology.: Elsevier; 2018
Whitaker SB, Waldron CA. Central giant cell lesions of the jaws. A clinical, radiologic, and histopathologic study. Oral Surg Oral Med Oral Pathol. 1993; 75:199-208 https://doi.org/10.1016/0030-4220(93)90094-k
Patel D, Minhas G, Johnson P. A recurrent central giant cell granuloma in a young patient and orthodontic treatment: a case report. J Orthod. 2016; 43:306-313 https://doi.org/10.1080/14653125.2016.1226566
Orhan E, Erol S, Deren O Idiopathic bilateral central giant cell reparative granuloma of jaws: a case report and literature review. Int J Pediatr Otorhinolaryngol. 2010; 74:547-552 https://doi.org/10.1016/j.ijporl.2010.02.006
de Lange J, van den Akker HP, van den Berg H. Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 104:603-615 https://doi.org/10.1016/j.tripleo.2007.04.003
de Lange J, van den Akker HP, Klip H. Incidence and disease-free survival after surgical therapy of central giant cell granulomas of the jaw in The Netherlands: 1990–1995. Head Neck. 2004; 26:792-795 https://doi.org/10.1002/hed.20069
Kaugars GE, Niamtu J, Svirsky JA. Cherubism: diagnosis, treatment, and comparison with central giant cell granulomas and giant cell tumors. Oral Surg Oral Med Oral Pathol. 1992; 73:369-74 https://doi.org/10.1016/0030-4220(92)90137-f
Weidner N. Modern Surgical Pathology.London: Elsevier Health Sciences; 2009

Multidisciplinary management of a central giant cell lesion: a case report

From Volume 15, Issue 1, January 2022 | Pages 35-39

Authors

Niecoo Tajmehr

BDS, MFDS, PGCert (Med Ed)

Specialty Registrar in Orthodontics, Norfolk and Norwich University Hospital

Articles by Niecoo Tajmehr

Email Niecoo Tajmehr

Hanieh Javidi

BDS, MFDS, MDPH, MClinDent (Orth), MOrth, FDS (Orth)

Senior Clinical Lecturer and Honorary Consultant in Orthodontics, Division of Dentistry, School of Medical Sciences, University of Manchester

Articles by Hanieh Javidi

David Laugharne

BMBS, BDS, BMedSci, FDS RCS, FRCS (OMFS)

Consultant in Oral and Maxillofacial Surgery, United Hospitals of Derby and Burton NHS Foundation Trust

Articles by David Laugharne

Anne-Marie Smith

BDS, FDS RCS(Eng), MSc(Lond), MOrth RCS(Eng), FDS(Orth) RCS(Eng)

Consultant Orthodontist, Royal Derby Hospital, Uttoxeter New Road, Derby DE22 3NE, UK

Articles by Anne-Marie Smith

Abstract

This case report describes the diagnosis and management of a central giant cell lesion in a young, healthy patient. The article outlines the differences between central giant cell lesions and their counterparts, peripheral giant cell lesions. More crucially, it highlights the challenge in distinguishing these lesions, which are almost identical histopathologically.

CPD/Clinical Relevance: This case describes the difficulties that can be faced by clinicians in differentiating between peripheral giant cell lesions and central giant cell lesion. It also highlights the need for specialist multidisciplinary input in managing the surgical and orthodontic implications of these lesions.

Article

Central giant cell lesions are benign, but sometimes aggressive, neoplasms of the jaws.1,2,3 They can cause cortical bone expansion, tooth displacement/mobility and root resorption.3 In comparison, peripheral giant cell lesions are benign reactive lesions that arise from the soft tissues, often in response to mucosal trauma.4

A 9-year-old female was referred to the oral and maxillofacial surgery (OMFS) department at the Royal Derby Hospital by her general dental practitioner (GDP). Medically, the patient was fit and well, the reason for referral being a possible haematoma in the lower right lateral incisor, canine and first premolar region (LR2–LR4).

On initial presentation, the patient had no complaints of pain or soreness. A detailed history revealed that the intra-oral swelling in the lower right quadrant had been present for approximately 12 months and had not changed size during this time period. There was no history of trauma or previous treatment to the area.

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